Xiaoping Gu Selected Research

Remifentanil (Ultiva)

3/2017	N-acetyl-cysteine attenuates remifentanil-induced postoperative hyperalgesia via inhibiting matrix metalloproteinase-9 in dorsal root ganglia.
1/2017	Intraoperative electroacupuncture relieves remifentanil-induced postoperative hyperalgesia via inhibiting spinal glial activation in rats.
1/2017	Activation of spinal alpha-7 nicotinic acetylcholine receptor shortens the duration of remifentanil-induced postoperative hyperalgesia by upregulating KCC2 in the spinal dorsal horn in rats.
7/2015	Intrathecal injection of KN93 attenuates paradoxical remifentanil-induced postoperative hyperalgesia by inhibiting spinal CaMKII phosphorylation in rats.
5/2015	Neuron-restrictive silencer factor in periaqueductal gray contributes to remifentanil-induced postoperative hyperalgesia via repression of the mu-opioid receptor.
1/2015	Activation of spinal alpha-7 nicotinic acetylcholine receptor attenuates remifentanil-induced postoperative hyperalgesia.
9/2014	[Changes of Mu-opioid receptor and neuron-restrictive silencer factor in periaquductal gray in mouse models of remifentanil-induced postoperative hyperalgesia].
7/2014	Intrathecal administration of roscovitine prevents remifentanil-induced postoperative hyperalgesia and decreases the phosphorylation of N-methyl-D-aspartate receptor and metabotropic glutamate receptor 5 in spinal cord.
4/2014	Intrathecal injection of JWH015 attenuates remifentanil-induced postoperative hyperalgesia by inhibiting activation of spinal glia in a rat model.
11/2013	Antinociception and prevention of hyperalgesia by intrathecal administration of Ro 25-6981, a highly selective antagonist of the 2B subunit of N-methyl-D-aspartate receptor.

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Xiaoping Gu Research Topics

Disease

44	Pain (Aches) 03/2022 - 10/2007
37	Hyperalgesia 01/2022 - 10/2007
16	Bone Neoplasms (Bone Cancer) 11/2020 - 10/2010
13	Neuralgia (Stump Neuralgia) 02/2019 - 10/2010
12	Cognitive Dysfunction 08/2022 - 01/2012
12	Neoplasms (Cancer) 01/2019 - 01/2004
11	Postoperative Pain 03/2022 - 12/2009
6	Inflammation (Inflammations) 04/2020 - 08/2011
5	Neuroinflammatory Diseases 08/2022 - 01/2012
5	Postoperative Cognitive Complications 03/2022 - 01/2012
5	Chronic Pain 03/2022 - 07/2014
5	Hypersensitivity (Allergy) 01/2022 - 01/2017
4	Ischemia 10/2021 - 01/2012
4	Breast Neoplasms (Breast Cancer) 01/2019 - 10/2007
4	Surgical Wound 03/2017 - 09/2014
4	Cancer Pain 09/2014 - 08/2011
3	Post-Traumatic Stress Disorders (Post Traumatic Stress Disorder) 01/2022 - 01/2016
3	Mitochondrial Diseases (Mitochondrial Disease) 01/2022 - 10/2021
3	Osteosarcoma (Osteogenic Sarcoma) 01/2018 - 07/2012
3	Melanoma (Melanoma, Malignant) 06/2010 - 10/2007
2	Insulin Resistance 01/2021 - 01/2020
2	Type 2 Diabetes Mellitus (MODY) 01/2021 - 01/2020
2	Hyperglycemia 01/2021 - 01/2020
2	Postoperative Nausea and Vomiting (PONV) 03/2020 - 09/2017
2	Memory Disorders (Memory Loss) 01/2020 - 01/2018
2	Liver Neoplasms (Liver Cancer) 08/2019 - 01/2019
2	Infections 08/2019 - 06/2011
2	Spinal Cord Injuries (Spinal Cord Injury) 01/2018 - 08/2017
2	Hypothermia 10/2017 - 01/2017
2	Peripheral Nerve Injuries 01/2014 - 07/2013
2	Pancreatic Neoplasms (Pancreatic Cancer) 06/2010 - 10/2007
1	Pneumonia (Pneumonitis) 08/2022
1	COVID-19 08/2022

Drug/Important Bio-Agent (IBA)

15	N-Methyl-D-Aspartate Receptors (NMDA Receptors)IBA 11/2016 - 01/2008
13	Proteins (Proteins, Gene)FDA Link 01/2021 - 01/2012
12	CytokinesIBA 01/2022 - 12/2008
11	Isoflurane FDA LinkGeneric 08/2022 - 03/2016
11	Remifentanil (Ultiva)FDA Link 03/2017 - 12/2009
9	Analgesics (Analgesic Drugs)IBA 03/2022 - 11/2013
8	Tumor Necrosis Factor-alpha (Tumor Necrosis Factor)IBA 01/2020 - 10/2007
6	Interleukin-6 (Interleukin 6)IBA 03/2022 - 01/2012
6	Messenger RNA (mRNA)IBA 03/2019 - 10/2007
6	salicylhydroxamic acid (SHAM)IBA 01/2018 - 10/2010
5	Cannabinoid Receptors (Cannabinoid Receptor)IBA 10/2020 - 08/2011
5	Estrogen ReceptorsIBA 07/2020 - 05/2015
5	N-Methylaspartate (NMDA)IBA 01/2019 - 12/2009
4	Antisense OligonucleotidesIBA 11/2020 - 07/2013
4	Dexmedetomidine FDA Link 03/2020 - 08/2017
4	InterleukinsIBA 01/2020 - 04/2015
4	Calcium-Calmodulin-Dependent Protein Kinase Type 2IBA 02/2019 - 09/2014
4	Nicotinic Receptors (Nicotinic Acetylcholine Receptor)IBA 08/2017 - 01/2015
3	General AnestheticsIBA 08/2022 - 01/2021
3	Phosphotransferases (Kinase)IBA 01/2020 - 07/2014
3	Ketamine FDA LinkGeneric 01/2020 - 12/2009
3	N- (1- azabicyclo(2.2.2)oct- 3- yl)furo(2,3- c)pyridine- 5- carboxamideIBA 01/2019 - 01/2015
3	1- (5- chloro- 2,4- dimethoxyphenyl)- 3- (5- methylisoxazol- 3- yl)ureaIBA 01/2019 - 01/2015
3	Opioid Analgesics (Opioids)IBA 01/2017 - 12/2009
3	CB2 Cannabinoid ReceptorIBA 01/2017 - 08/2011
3	Cyclic AMP Response Element-Binding Protein (Cyclic AMP-Responsive DNA-Binding Protein)IBA 01/2017 - 07/2013
3	RoscovitineIBA 09/2014 - 07/2012
3	NR2B NMDA receptorIBA 11/2013 - 12/2009
2	Anesthetics (Anesthetic Agents)IBA 08/2022 - 01/2015
2	Metformin (Glucophage)FDA LinkGeneric 08/2022 - 01/2021
2	Pharmaceutical PreparationsIBA 08/2022 - 01/2022
2	Transcription Factors (Transcription Factor)IBA 01/2022 - 01/2018
2	Saline SolutionIBA 01/2022 - 09/2017
2	Small Interfering RNA (siRNA)IBA 01/2022 - 01/2016
2	Insulin (Novolin)FDA Link 01/2021 - 01/2020
2	Pioglitazone (Actos)FDA Link 11/2020 - 04/2020
2	GTP-Binding Proteins (G-Protein)IBA 07/2020 - 01/2020
2	Matrix Metalloproteinase 9 (Gelatinase B)IBA 07/2020 - 03/2017
2	Cysteine (L-Cysteine)FDA Link 07/2020 - 03/2017
2	Dexamethasone (Maxidex)FDA LinkGeneric 03/2020 - 06/2014
2	Biomarkers (Surrogate Marker)IBA 08/2019 - 04/2015
2	Hepatitis B Surface Antigens (HBsAg)FDA Link 08/2019 - 01/2019
2	RNA Splicing FactorsIBA 01/2019 - 05/2015
2	Phenobarbital (Luminal)FDA Link 01/2018 - 05/2015
2	MelatoninIBA 01/2018 - 03/2016
2	Interleukin-10 (Interleukin 10)IBA 01/2018 - 04/2015
2	JHW 015IBA 01/2017 - 10/2015
2	Minocycline (Cyclops)FDA LinkGeneric 01/2017 - 01/2016
2	Brain-Derived Neurotrophic Factor (BDNF)IBA 01/2017 - 01/2016
2	CannabinoidsIBA 01/2017 - 08/2011
2	Nitric Oxide Synthase Type I (Neuronal Nitric Oxide Synthase)IBA 01/2016 - 06/2014
2	Therapeutic UsesIBA 01/2016 - 01/2012
2	bovine adrenal medulla 8-22IBA 01/2016 - 01/2015
2	KN 93IBA 07/2015 - 09/2014
2	mu Opioid Receptors (mu Opioid Receptor)IBA 05/2015 - 09/2014
2	RE1-silencing transcription factorIBA 05/2015 - 09/2014
2	Tyrosine (L-Tyrosine)FDA Link 07/2014 - 12/2009
2	Cyclin-Dependent Kinase 5IBA 07/2014 - 07/2012
2	Mifepristone (RU 486)FDA Link 06/2014 - 10/2007
2	Interleukin-17 (Interleukin 17)IBA 06/2010 - 12/2008
2	Triamcinolone (Aristocort)FDA Link 01/2008 - 10/2007

Therapy/Procedure

14	Spinal Injections 10/2020 - 01/2012
13	Therapeutics 03/2022 - 10/2010
12	Anesthesia 03/2022 - 03/2016
4	Analgesia 03/2022 - 08/2011
4	Intraperitoneal Injections 07/2020 - 10/2010
4	General Anesthesia 10/2017 - 01/2015